Little Snitch reports outgoing connections from Mach Kernel -- am I infected?

I monitor all my traffic using Little Snitch. Recently, I've noticed strange IP addresses making connections to the "mach_kernel" process. Most of these IP addresses seem to originate from other programs (for example, I might see a Google address connected to mach_kernel when I'm browsing Gmail via my browser).

Is my Mac infected? The main concern here is that I have a virus which is MitMing traffic of other programs on my box. How can I tell if this is the case?