My Mac recently using RAM like hell?

I have 8 GB of ram and I have only 1.25GB free memory left, not enough to run 2 tabs of gmail. for chrome keep asking me to kill the process of my Gmail which 2-3 days ago I'm always have like 2-3GB free memory after opening 2 gmail accounts and some others websites.

I also installed auto memory clean to help me get more memory back but recently when my mac start, a few minutes later memory almost dropped to 0GB so my memory cleaner app keep to clean memory after that memory consuming so fast and repeat above process again. Memory clean doesn't solve my problem in a long term.

I have closed all the apps to free memory and I see that when idle I should have more memory back but it's not.

So I looked into Activity Monitor and Memory clean app, I saw 2 things that consuming lots of memory which I don't think it's true.

I'm trying to use cleanmymac 2 to help me solve the issue specially to kick away some file cache problem, but I don't see any difference.